Talk:Cytokine

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This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Jenwang14.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 18:55, 16 January 2022 (UTC)

Pronunciation (Introduction?)

Could the article tell us how to pronounce the term? - sigh-toe-ky-knee (four syllables)? or sigh-toe-kine (three)? Once you know the term's (Greek) origin, the four-syllable version is the obvious candidate .. but most readers will want to use the same pronunciation as most other people - and it's hard to guess what % (ie 'most' or not, of 'other people') have read the article / know the Greek origin! (Usage may well be divided / controversial / evolving .. making guidance harder to provide .. but also making guidance more necessary!)

Of course, the pronunciation ought to be stated in the usual IPA /phonemic style/ .. I haven't tried to do that in this post, as it's well beyond my editing skills.

SquisherDa (talk) 06:08, 25 June 2010 (UTC)

The OED says it's three syllables. GrizzlySound (talk) 14:33, 3 January 2014 (UTC)

Major deletion of duplicated/triplicated sections

Looks as if some one was practising editing on the article, and all sections were duplicated (some triplicated!). While I compared the duplicated sections side by side, I may have missed some additions. Please excuse and correct any errors which crept in... Christom (talk) 07:24, 15 March 2013 (UTC)

Pain pathways & clinical applications

Hi all, I am considering adding a section about the effect of cytokines in the pain receptor pathway, and another section on current cytokine applications in of treatment of various disorders. I will update this post with relevant information as I go along and would appreciate any feedback about the edits. Thanks!

Here is an outline of my proposed edits/additions:

1. Edit structure of into paragraph to eliminate redundancy

2. Expand upon discovery of cytokines section (historical review article on cytokines: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140102/)

3. Discuss role in auto-immunity, specifically in the categories: -viral response ("Viruses use these gene products to prevent the host’s immune response intended to eliminate the infection") -bacterial response -pain pathways -other

4. Adding sections that expand upon the multiple categories of cytokines (would this be excessive if we can just link the related wiki pages?) --> similar to what someone did with the Receptors section, with "Main article: Cytokine receptor"

5. expand upon medical use as direct drugs and therapeutic targets -chronic diseases, cytokine balance is usually "off"

Update: I have added the following segment-

"Cytokines also play a role in anti-inflammatory pathways and are a possible therapeutic treatment for pathological pain from inflammation or peripheral nerve injury.[12] There are both pro-inflammatory and anti-inflammatory cytokines that regulate this pathway."

I plan to add more but any general comments to the direction of this addition? Jenwang14 (talk) 15:56, 28 April 2016 (UTC)

1. read WP:LEAD
2. ok in theory but that source is nine years old
3. this seems confused
4. unclear how this fits in Classification section
5. sure.

- Jytdog (talk) 17:54, 5 May 2016 (UTC)

External links modified

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Advances in Cytokine Engineering

Hello,

I was looking to add a section on advancements in cytokine engineering. The use of cytokines as therapeutics is discussed in the article and may benefit from a discussion on how these cytokines and their receptor interactions have motivated targeted immunotherapies that bias immune cell activation or suppression depending on disease specifics.

Because of their significance across various modes of cell signaling, research groups have focused on cytokines as mediators of various immunoregulatory actions and as the basis for next-generation therapeutics. While cytokines present a robust method for transient cell-cell communication, their use as therapeutics is often hampered by their low toxicity threshold and propensity for off-target receptor activation.[1] To this end, antibody therapies based on the cytokine-receptor complex present a spatially controlled method for therapeutic design across a range of human diseases.

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697184/ — Preceding unsigned comment added by Jonahronah (talk • contribs) 00:15, 4 December 2019 (UTC)

Table

Should we consider making a table to make it easer to quickly get an overview of what cytokines there is? one could take inspiration from a side like: https://www.sinobiological.com/resource/cytokines/cytokines-types

and then have a table structure like Cytokine | Source | Target | Biological Role

Much like we have a list of human Hormons: https://en.wikipedia.org/wiki/List_of_human_hormones Claes Lindhardt (talk) 09:23, 10 December 2022 (UTC)

Most of them have wiki sites already, like: https://en.wikipedia.org/wiki/Interleukin_2, https://en.wikipedia.org/wiki/Interleukin_7 and https://en.wikipedia.org/wiki/Interleukin_3 . Would it not be very usefull with an easy to access overview of them all? which was also easily sortable to the 4 params mentioned above? Claes Lindhardt (talk) 19:07, 10 December 2022 (UTC)

Maybe we could even have a picture in the list? Claes Lindhardt (talk) 19:28, 10 December 2022 (UTC)

of course we would need a more compleate list to take inspiration from maybe like: https://www.ncbi.nlm.nih.gov/books/NBK499840/ Claes Lindhardt (talk) 19:29, 10 December 2022 (UTC)

There is already a list of interleukines: https://en.wikipedia.org/wiki/Interleukin maybe we could build on top of that? Claes Lindhardt (talk) 19:30, 10 December 2022 (UTC)